Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACSÂź)
25 mg
6%
Top Medical Research Studies
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell culturesâ2D monolayers and 3D spheroidsâresponded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Read More
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Read More
Most Useful Reviews
9
Reduces anxiety levels
6 people found this helpful
This medication significantly improves my sleep and alleviates the persistent anxiety that troubled me. Now, I feel calm, and even my friends and family have noticed a dramatic change. This is due to 5-HTP enhancing the brain's serotonin production, leading to noticeable improvements in mood.
Read More
9
Supports cognitive function
1 people found this helpful
This vitamin works wonders for cognition. The P5P vitamin B6 contains quality ingredients and comes in small capsules, making it easy to take. It supports the nervous system and effectively meets the brain's needs when combined with other supplements. I wholeheartedly recommend it!
Read More
7.5
Boosted energy levels
7 people found this helpful
I began taking this supplement with zinc gluconate as I suspect I may have pyroluria. Regardless of that, I noticed a significant boost in my energy levels and a reduction in 'brain fog' from the very first day of taking it. I have tried regular B6 before without similar benefits. Both my husband and father have also noticed a similar effect. I would highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell culturesâ2D monolayers and 3D spheroidsâresponded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Read More
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces anxiety levels
6 people found this helpful
This medication significantly improves my sleep and alleviates the persistent anxiety that troubled me. Now, I feel calm, and even my friends and family have noticed a dramatic change. This is due to 5-HTP enhancing the brain's serotonin production, leading to noticeable improvements in mood.
Read More
9
Supports cognitive function
1 people found this helpful
This vitamin works wonders for cognition. The P5P vitamin B6 contains quality ingredients and comes in small capsules, making it easy to take. It supports the nervous system and effectively meets the brain's needs when combined with other supplements. I wholeheartedly recommend it!
Read More
7.5
Boosted energy levels
7 people found this helpful
I began taking this supplement with zinc gluconate as I suspect I may have pyroluria. Regardless of that, I noticed a significant boost in my energy levels and a reduction in 'brain fog' from the very first day of taking it. I have tried regular B6 before without similar benefits. Both my husband and father have also noticed a similar effect. I would highly recommend it.
Read More
7.5
Protects cognitive health
7 people found this helpful
P-5-P effectively protects DNA and is vital for cognitive function and brain health. We take vitamin B6 for energy and as support for the nervous system and adaptation to stress. It also plays a critical role in synthesising dopamine, serotonin, GABA, and histamine, and crucially, it guards against accelerated ageing.
Read More
7.5
Enhanced memory function
5 people found this helpful
P5P not only boosts mental energy but may also support memory formation due to its neurotransmitter properties. This form of B6 is highly absorbable and ideal for enhancing overall brain health. I purchased it to improve my memory, as it acts as a co-factor for other minerals to function properly.
Read More
Frequently Asked Questions
7.5
Boosted energy levels
7 people found this helpful
I began taking this supplement with zinc gluconate as I suspect I may have pyroluria. Regardless of that, I noticed a significant boost in my energy levels and a reduction in 'brain fog' from the very first day of taking it. I have tried regular B6 before without similar benefits. Both my husband and father have also noticed a similar effect. I would highly recommend it.
9
Improved brain efficiency
1 people found this helpful
My cognitive abilities are sharper and more efficient. The capsules are easy to swallow, and I recommend this to anyone looking to boost their brain function.
7.5
Enhanced memory function
5 people found this helpful
P5P not only boosts mental energy but may also support memory formation due to its neurotransmitter properties. This form of B6 is highly absorbable and ideal for enhancing overall brain health. I purchased it to improve my memory, as it acts as a co-factor for other minerals to function properly.
9
Supports brain function
This has proven to be very useful, particularly for brain function.
9
Reduces anxiety levels
6 people found this helpful
This medication significantly improves my sleep and alleviates the persistent anxiety that troubled me. Now, I feel calm, and even my friends and family have noticed a dramatic change. This is due to 5-HTP enhancing the brain's serotonin production, leading to noticeable improvements in mood.
7.5
Calms brain sensitivity
This supplement has helped to soothe my brain's sensitivity to stimuli, stress, and overthinking, especially when taken with 5-HTP.
9
Supports cognitive function
1 people found this helpful
This vitamin works wonders for cognition. The P5P vitamin B6 contains quality ingredients and comes in small capsules, making it easy to take. It supports the nervous system and effectively meets the brain's needs when combined with other supplements. I wholeheartedly recommend it!
7.5
Protects cognitive health
7 people found this helpful
P-5-P effectively protects DNA and is vital for cognitive function and brain health. We take vitamin B6 for energy and as support for the nervous system and adaptation to stress. It also plays a critical role in synthesising dopamine, serotonin, GABA, and histamine, and crucially, it guards against accelerated ageing.
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell culturesâ2D monolayers and 3D spheroidsâresponded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
References
- Moosa NY, Azeem SA, Lodge JK, Cheung W, Ahmed SU. Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. Int J Mol Sci. 2024;25. 10.3390/ijms251910428
- MartĂnez-Mendiola CA, Estrada JA, Zapi-ColĂn LĂ, Contreras-ChĂĄvez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. 10.1080/00207454.2023.2263815
